Amino- and polyaminophthalazin-1(2H)-ones: synthesis, coordination properties, and biological activity

• Zbigniew Malinowski,
• Emilia Fornal,
• Agata Sumara,
• Renata Kontek,
• Karol Bukowski,
• Beata Pasternak,
• Dariusz Sroczyński,
• Joachim Kusz,
• Magdalena Małecka and
• Monika Nowak

Beilstein J. Org. Chem. 2021, 17, 558–568, doi:10.3762/bjoc.17.50

• -929 cell line, proved that some amino derivatives of phthalazinone show interesting anticancer activities. The detailed synthesis, spectroscopic data, and biological assays are reported. Keywords: amination; complexes; cytotoxicity; Pd cross-coupling; phthalazinone; Introduction Phthalazine and its

Palladium nanoparticles supported on chitin-based nanomaterials as heterogeneous catalysts for the Heck coupling reaction

• Tony Jin,
• Malickah Hicks,
• Davis Kurdyla,
• Sabahudin Hrapovic,
• Edmond Lam and
• Audrey Moores

Beilstein J. Org. Chem. 2020, 16, 2477–2483, doi:10.3762/bjoc.16.201

• catalytic site in most cases [22], Pd(II) would be inactive towards oxidative addition of the electrophilic iodobenzene, leading to no product formation. Importantly, even if mild reducers were present to initiate the cycle and afford Pd(0), as is often the case in Pd cross coupling chemistry, the fact that

Influence of bulky yet flexible N-heterocyclic carbene ligands in gold catalysis

• Alba Collado,
• Scott R. Patrick,
• Danila Gasperini,
• Sebastien Meiries and
• Steven P. Nolan

Beilstein J. Org. Chem. 2015, 11, 1809–1814, doi:10.3762/bjoc.11.196

• ][25][26], has been applied by a number of research groups to metal-catalysed transformations, leading to improvements in catalytic activity over other known systems [27][28][29][30][31][32][33][34][35][36][37][38][39][40][41]. The ITent ligands have been successfully used in challenging Pd cross

• -coupling reactions and other Pd-promoted transformations [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41]. The electronic and steric properties of the ITent family have been determined [21][42][45] and compared to the parent ligand IPr. The observed trend for both